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. 2022 Aug 29;2(9):824–836. doi: 10.1038/s43587-022-00278-w

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 2 — a-d, Rapamycin treatment initiated on day 30 down-regulated TORC1 activity within 48 h and terminating rapamycin treatment on day 30 de-repressed TORC1 activity back to the levels of control flies within 48 h in heads, muscle, fat body and gut. Data are mean ± s.e.m. One-way ANOVA; Tukey’s multiple comparison test. N = 3 biological replicates, each consisting of 15 flies. e-f, Chronic (p = 9.95 ×10-05) and short-term (p = 0.029) rapamycin treatment extended lifespan of control flies and of flies over-expressing constitutively active S6K in the gut (chronic: p = 0.002, short-term treatment: p = 0.02, see also Supplementary Table 4). N = 200 flies per experimental group. Log-rank test and CPH analysis.