Extended Data Fig. 5. The rs1921622 A allele is associated with better cognitive performance in female APOE-ε4 carriers in the AIBL Aβ⁺ cohort.

Individual cognitive scores in (a) overall Aβ⁺ APOE-ε4 carriers (n = 122 G carriers [G/-], n = 53 A/A carriers), (b) male Aβ⁺ APOE-ε4 carriers (n = 63 G carriers [G/-], n = 24 A/A carriers), and (c) female Aβ⁺ APOE-ε4 carriers (n = 59 G carriers [G/-], n = 29 A/A carriers) stratified according to rs1921622 genotype. Test in the overall Aβ⁺ APOE-ε4 carriers, W = 3782.0, 3671.0, 3842.0, and 3319.0 for the effects of rs1921622 genotype on AIBL Preclinical Alzheimer Cognitive Composite (AIBLPACC) score, attention processing score, episodic recall score, and recognition score, respectively; test in the male Aβ⁺ APOE-ε4 carriers, W = 784.0, 727.0, 823.5, and 740.0 for the effects of rs1921622 genotype on AIBLPACC score, attention processing score, episodic recall score, and recognition score, respectively; test in the female Aβ⁺ APOE-ε4 carriers, W = 1087.0, 1115.5, 1083.0, and 916.5 for the effects of rs1921622 genotype on AIBLPACC score, attention processing score, episodic recall score, and recognition score, respectively. Data in box-and-whisker plots are presented with maximum, 75^th percentile, median, 25^th percentile, and minimum values; plus signs (+) denote mean values. Statistical tests are performed by Wilcoxon rank-sum test, with multiple testing correction. *FDR < 0.05, **FDR < 0.01, ***FDR < 0.001. FDR, false discovery rate.