Extended Data Fig. 6. The rs1921622 A allele is associated with slower gray matter atrophy in female APOE-ε4 carriers in the AIBL Aβ⁺ cohort.

(a, b) Individual baseline (a: n = 128 G carriers [G/-], and 55 A/A carriers) and longitudinal gray matter volume (b: n = 148 datapoints from 37 G/- carriers, and 55 datapoints from 14 A/A carriers) in overall Aβ⁺ APOE-ε4 carriers stratified by rs1921622 genotype. Test on baseline data: W = 4109.0, FDR = 0.109. Test on longitudinal data: β = −0.089 and −0.051 in G/- and A/A carriers, respectively; F = 3.830, FDR = 0.087. (c, d) Individual baseline (c: n = 64 G/- carriers, and 24 A/A carriers) and longitudinal gray matter volume (d: n = 98 datapoints from 25 G/- carriers, and 36 datapoints from 9 A/A carriers) in male Aβ⁺ APOE-ε4 carriers stratified by rs1921622 genotype. Test on baseline data: W = 852.0, FDR = 0.434. Test on longitudinal data: β = −0.069 and −0.053 in G/- and A/A carriers, respectively; F = 0.272, FDR = 0.607. (e, f) Individual baseline (e: n = 64 G/- carriers, and 31 A/A carriers) and longitudinal gray matter volume (f: n = 50 datapoints from 12 G/- carriers, and 19 datapoints from 5 A/A carriers) in female Aβ⁺ APOE-ε4 carriers stratified by rs1921622 genotype. Test on baseline data: W = 1240.0, FDR = 0.109. Test on longitudinal data: β = −0.159 and −0.027 in G/- and A/A carriers, respectively; F = 8.804. Data in box-and-whisker plots are presented with maximum, 75^th percentile, median, 25^th percentile, and minimum values; plus signs (+) denote mean values; data in regression lines are presented as slope (red/blue) and 95% confidence intervals (gray). Statistical tests on baseline data were performed by Wilcoxon rank-sum test, with multiple testing correction; and statistical tests on longitudinal data were performed by linear mixed model test, adjusted for baseline age and MRI scanners, with multiple testing correction. *FDR < 0.05, **FDR < 0.01, ***FDR < 0.001.