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. 2022 Jul 15;2(7):616–634. doi: 10.1038/s43587-022-00241-9

Extended Data Fig. 10. Elevated brain soluble ST2 level leads to decreased amyloid-beta phagocytosis by microglia in female 5XFAD mice.

Extended Data Fig. 10

(a, b) Microglial amyloid-beta (Aβ) uptake activity in the cortices of 4-month-old female 5XFAD mice after 28-day intracerebroventricular delivery of soluble ST2 (sST2)-Fc or Fc as a control. Representative distribution (a) and quantification (b) show the mean fluorescent intensity (MFI) of methoxy-X04-labeled Aβ in the methoxy-X04+ CD11b+ microglia (control: n = 7 mice, sST2: n = 7 mice). T = − 2.490 and −2.014 for the tests in microglial with medium Aβ uptake (MeX04MedCD11b+; left) and high Aβ uptake (MeX04HighCD11b+; right), respectively; P = 0.028 and 0.067, respectively. Data in bar charts are mean + SEM. Statistical tests were performed as two-sided unpaired Student’s t-tests. *P < 0.05, **P < 0.01, ***P < 0.001.