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. 2022 Jul 15;2(7):616–634. doi: 10.1038/s43587-022-00241-9

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 2 — (a) Individual plasma soluble ST2 (sST2) levels stratified by sex and disease phenotype (male: n = 132 healthy controls [HCs], n = 84 individuals with Alzheimer’s disease [AD]; female: n = 204 HCs, n = 193 individuals with AD). Test for effects of sex: β = −3.848 and −3.257 in HCs and individuals with AD, respectively; test for effects of AD: β = 1.926 and 2.235 in males and females, respectively. (b, c) Individual plasma sST2 levels stratified by APOE-ε4 genotypes and disease phenotype in (b) males (male ε4: n = 28 HCs, n = 29 individuals with AD; male non-ε4: n = 104 HCs, n = 55 individuals with AD), and (c) females (female ε4: n = 25 HCs, n = 71 individuals with AD; female non-ε4: n = 179 HCs, n = 122 individuals with AD). Test for effects of APOE-ε4: β = −1.809, −1.499, −0.248, and 2.425 in male HCs, male individuals with AD, female HCs, and female individuals with AD, respectively; test for effects of AD: β = 2.034, 1.098, 3.833, and 1.811 in male ε4, male non-ε4, female ε4, and female non-ε4, respectively. ε4, APOE-ε4 carriers; non-ε4, APOE-ε4 noncarriers. Data are presented as box-and-whisker plots including maximum, 75^th percentile, median, 25^th percentile, and minimum values; plus signs (+) denote corresponding mean values. Linear regression test, adjusted for age, cardiovascular disease status, body mass index (BMI), and education level, with multiple testing correction; ^#FDR < 0.05, ^##FDR < 0.01, ^###FDR < 0.001; *FDR < 0.05, **FDR < 0.01, ***FDR < 0.001. FDR, false discovery rate.