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. 2023 Mar 9;3(3):327–345. doi: 10.1038/s43587-023-00373-6

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 10 — Canonical EC ligands and their cognate receptors in OLG (a) or in NRP (b) are shown in each paradigm (Aging, RJV, AGA). In all panels of ligand-receptor interactions, node color represents the magnitude of the DGE (logFC as estimated by DGE) such that the most significantly up-regulated genes are in magenta, and the downregulated genes are in blue. Node borders indicate multiple testing corrected Benjamini-Hochberg FDR for statistical significance of DGE as calculated by edgeR. Edge color represents the sum of scaled differential expression magnitudes from each contributing node, while width and transparency are determined by the magnitude of the scaled differential expression (see details in the Methods section).