Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Mar 9;3(3):327–345. doi: 10.1038/s43587-023-00373-6

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 2 — a–e, Subpopulation analysis of cell types grouped in five distinct cell classes: OLG lineage and OEGs (n = 41,873 cells) (a), astroependymal cells and NSCs (n = 19,520 cells) (b), neuronal lineage (n = 20,869 cells) (c), vasculature cells (n = 10,438 cells) (d) and immune cells (n = 12,629 cells) (e). q, quiescent; p, proliferating; c, committed, nf, newly formed; mf, myelin-formin; mt, mature. f, UMAP subpopulation analysis of EC clusters (n = 6,218 cells). g, UMAP subpopulation of EC clusters, stratified by animal type. h, Violin plot of delineating markers of ECs, as Cldn5, Slc1a3, Lrg1, Omp and Plvap. i, UMAP overlay of EC zonation markers along the arteriovenous axis curated from the literature^41–43. Markers in left-to-right order: large arteries: Fbln5; arterial: Gkn3; capillary–arterial: Tgfb2; capillary: Mfsd2a; capillary: Cxcl12; capillary–venous: Car4; venous: Slc38a6; large veins: Lcn2; and large vessels: Vcam1.