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. 2023 Mar 9;3(3):327–345. doi: 10.1038/s43587-023-00373-6

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — a, Dot-plot representation of senescence-associated marker genes curated from the literature^76,78, permuted against each cell type in aging, RJV and AGA with fast GSEA. The inverse log₁₀(P_adj) values for multiple comparisons (Benjamini–Hochberg) reflect the size of the dot and NESs reflect color from blue (negative enrichment) to magenta (positive enrichment). b, Representative RNA in situ images of mouse cortices showing Cdkn1a puncta in Pecam1⁺ ECs in YX, OY, OO and OX mice. Scale bars, 20 µm. c, Violin and boxplot representation of RNA quantification (n = 6 biologically independent animals) by two-tailed Welch’s t-test with no multiple comparison adjustment for significance. P values: OY–YX: 0.810 (95% CI −0.930, 1.190); OY–OO: 0.0484 (95% CI −1.670, −0.006); OY–OX: 0.0000874 (95% CI −3.063, −1.025); and OO–OX: 0.0251 (95% CI −2.260, −0.151). NS P > 0.05, ^*P ≤ 0.05, ^**P ≤ 0.01, ^***P ≤ 0.001 and ^****P < 0.0001. Boxplot minimum is the smallest value within 1.5× the IQR below the 25th percentile and maximum is the largest value within 1.5× the IQR above the 75th percentile. Boxplot center is the 50th percentile (median) and box bounds are the 25th and 75th percentiles. Outliers are >1.5× and <3× the IQR.

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