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. 2023 Feb 24;30(5):1155–1165. doi: 10.1038/s41418-023-01126-z

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© The Author(s) 2023, corrected publication 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A Schematic representation of the treatment of murine tumor organoids seeded as single cells with recombinant TGFβ1 and the timing of quantification of gene expression signatures. B–E mRNA expression levels of IL-6 family cytokines Il6, Lif, and Il11 (B); IL-6 family cytokine receptors il6st (C); Il6r, Lifr, and Il11r (D), and the IL-6 cytokine family target gene, Socs3 (E), 3 days post treatment with TGFβ1. Each dot represents an individual organoid. Organoids are grouped into glandular (G) and solid (S) types. Data includes three biological replicates and is presented as log10 fold change relative to the vehicle (white) control (mean ± SEM). *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, paired t-test.