TABLE 5.
Primary diagnoses and concomitant pathologies
| Concomitant pathologies | |||||
|---|---|---|---|---|---|
| Primary diagnoses | ADNC | Amyloid plaques | Amyloid angiopathy | α‐Synuclein pathology | |
| Tauopathy | Alzheimer's disease (41) | N.A. | N.A. | 15/41 (36.6%) | 5/22 (22.7%) |
| Frontotemporal lobar degeneration—Tau (2) | N.A. | 0 | 0 | 0 | |
| Progressive supranuclear palsy (8) | 3/8 (37.5%) | 2/6 (33.3%) | 1/6 (16.6%) | ‐ | |
| Corticobasal degeneration (6) | 3/6 (50.0%) | 2/5 (40.0%) | 1/5 (20.0%) | 1/4 (25.0%) | |
| Synucleinopathy | Dementia with lewy bodies (16) | 13/16 (81.3%) | 13/16 (81.3%) | 6/16 (37.5%) | N.A. |
| Parkinson's disease (2) | 1/2 (50.0%) | 1/2 (50.0%) | 0 | N.A. | |
| Multiple system atrophy (6) | 3/6 (50.0%) | ‐ | ‐ | N.A. | |
| TDP‐43 Proteinopathy | Frontotemporal lobar degeneration—TDP (6) | 4/6 (66.7%) | 2/6 (33.3%) | 1/6 (16.7%) | 1/4 (25.0%) |
| Amyotrophic lateral sclerosis (27) | 8/14 (57.1%) | 4/11 (36.4%) | 0 | ‐ | |
| Huntington's disease (15) | 2/6 (33.3%) | 1/6 (16.7%) | 0 | ‐ | |
| Creutzfeldt–Jakob disease (56) | 26/38 (68.4%) | 18/38 (47.4%) | 11/38 (28.9%) | 1/37 (2.7%) | |
Note: For each subgroup, the number of headcount (n) is specified.
Abbreviations: AD, Alzheimer's disease; ADNC, Alzheimer's disease neuropathologic change; FTLD, frontotemporal lobar degeneration; NA, not applicable.