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. 2023 May 2;14:2518. doi: 10.1038/s41467-023-38245-7

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a Schematic illustrating the route of 4T1 tumor rechallenge assay. Apart from the control group, all tumor-free mice were harvested from Group V (LDH@aPD-1@CC). n = 8 mice per group. Individual (b) and average (c) tumor growth kinetics per group. d Survival of mice in different rechallenge groups. For (c), the curve ended when the first mouse in the corresponding group died; statistical significance was calculated via one-way ANOVA with Tukey’s multiple comparisons; data are presented as the mean ± SD. For (d), statistical significance was calculated via the log-rank (Mantel‒Cox) test by comparison with the control group. ****p < 0.0001. Source data are provided as a Source Data file.