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. 2022 Nov 9;18(8):1818–1826. doi: 10.4103/1673-5374.360242

Figure 2.

Figure 2

Effects of exendin-4 and linagliptin on mouse behavior.

(A) Representative locomotor activity tracking map in the OFT. Blue boxes indicate the total area, while green boxes indicate the central area. (B–D) Total movement distance, time spent in the central area, and number of times that mice reared up on their hind legs in the OFT (n = 10). (E) Latency in the rotarod test (n = 15). (F) Latency in the pole test (n = 15). (G) Muscle strength score for the inverted screen test (n = 15). (H) Hindlimb clasping test score (n = 15). (I) Maximum running variation from the gait analysis (n = 10). Data are presented as mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001, vs. CON; #P < 0.05, ####P < 0.0001, vs. MPTP (one-way analysis of variance followed by Tukey’s post hoc test). CON: Control; EX-4: exendin-4; LINA: linagliptin; MPTP: 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; OFT: open field test.