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. 2022 Nov 9;18(8):1818–1826. doi: 10.4103/1673-5374.360242

Figure 8.

Figure 8

Effects of exendin-4 and linagliptin on pyroptosis in the SN of PD mice.

(A) Representative western blot image of GSDMD N-terminus expression in the SN. (B) Quantification of GSDMD N-terminus protein expression level. (C) LDH content in the serum of mice. Data are shown as mean ± SD (n = 3). *P < 0.05, **P < 0.01, vs. CON; #P < 0.05, ##P < 0.01, ###P < 0.001, vs. MPTP (one-way analysis of variance followed by Tukey’s post hoc test). CON: Control; EX-4: exendin-4; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; GSDMD: gasdermin D; LDH: lactate dehydrogenase; LINA: linagliptin; MPTP: 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; PD: Parkinson’s disease; SN: substantia nigra.