TABLE 2.
Pharmacokinetic parameters of tacrolimus in the presence and absence of PRE in a repetitive-dose study. (Cmax, observed maximum plasma concentration; Tmax, time to reach Cmax; AUC, area under concentration–time curve; MRT, mean residence time; Vz, the volume of distribution during terminal phase; and Cl, clearance).
| S. No | Parameter | Unit | TAC | TAC + PRE single-dose | TAC + PRE repetitive-dose |
|---|---|---|---|---|---|
| 1 | Cmax | ng/ml | 9.03 ± 1.21 | 66.27 ± 12.58 | 22.48 ± 3.07 |
| 2 | AUC0-12 | ngh/ml | 54.63 ± 14.70 | 338.81 ± 26.37 | 149.18 ± 11.02 |
| 3 | AUC0-inf | ngh/ml | 61.91 ± 17.37 | 342.45 ± 28.60 | 153.08 ± 13.24 |
| 4 | t1/2 | Hr | 0.12 ± 0.04 | 0.20 ± 0.03 | 0.15 ± 0.03 |
| 5 | Tmax | Hr | 0.91 ± 0.18 | 0.83 ± 0.23 | 0.58 ± 0.18 |