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. 2023 Apr 19;14:1139915. doi: 10.3389/fimmu.2023.1139915

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Copyright © 2023 Jenkins, Phan Tran, Flores, Kupferwasser, Pickering, Zheng, Gjertson, Ross, Schaenman, Miller, Yeaman and Reed

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Response to SARS-CoV-2 vaccination in LA-SPARTA participants differs with prior infection. (A) shows the concentration of RBD over time according to age. Participants over 55 years of age were compared to all participants below 55 years of age. (B) shows the concentration of RBD over time according to gender. (C) shows the concentration of RBD over time according to race/ethnicity. (D) shows the concentration of RBD over time according to prior infection status before vaccination. (E) shows only the difference in RBD concentration in participants who were vaccinated over the course of the study, using the first available sample after vaccination (regardless of timing after vaccination) according to whether they had a prior infection at enrollment and prior to vaccination. The change in RBD concentration is also shown between the pre-infection and post-infection blood samples. *** designates P >0.001 and **** designates P >0.0001. ns, not significant.