| Reviewer name and names of any other individual's who aided in reviewer | Nagasuma Chandra |
| Do you understand and agree to our policy of having open and named reviews, and having your review included with the published papers. (If no, please inform the editor that you cannot review this manuscript.) | Yes |
| Is the language of sufficient quality? | Yes |
| Please add additional comments on language quality to clarify if needed | |
| Are all data available and do they match the descriptions in the paper? | Yes |
| Additional Comments | |
| Are the data and metadata consistent with relevant minimum information or reporting standards? See GigaDB checklists for examples <a href="http://gigadb.org/site/guide" target="_blank">http://gigadb.org/site/guide</a> | Yes |
| Additional Comments | |
| Is the data acquisition clear, complete and methodologically sound? | Yes |
| Additional Comments | |
| Is there sufficient detail in the methods and data-processing steps to allow reproduction? | Yes |
| Additional Comments | It would be useful if the authors could comment on how the models vary between the two species and with respect to M. tuberculosis. Specifically, a note on how the authors deal with alternate enzymes and whether they included enzymes specific to each species, would be helpful. |
| Is there sufficient data validation and statistical analyses of data quality? | Yes |
| Additional Comments | |
| Is the validation suitable for this type of data? | Yes |
| Additional Comments | A figure depicting the overall capability of the models would be useful |
| Is there sufficient information for others to reuse this dataset or integrate it with other data? | Yes |
| Additional Comments | |
| Any Additional Overall Comments to the Author | Genome-scale metabolic models are useful to the community as they can be used to address a variety of questions. It would be useful if the authors could include a section on the comparative performance of the models and link it to the known metabolic capability of these microbes. |
| Recommendation | Minor Revision |