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. 2023 May 3;42(5):112503. doi: 10.1016/j.celrep.2023.112503

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© 2023 The Author(s)

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Cryo-EM structures of XG005 complexed with Omicron S trimer

(A) XG005 binds to Omicron S trimer in three states: one “up” RBD and two “down” with two Fabs (UDD with two Fabs), one “up” RBD and two “down” with three Fabs (UDD with three Fabs), and two “up” RBDs and one “down” RBD with three Fabs (UDU with three Fabs). Two perpendicular views of Omicron S-XG005 depict the surface. The XG005 VH/CH and VL/CL domains are colored in orange and yellow, respectively. Three S protomers of Omicron S trimer are colored in blue, green, and purple, respectively.

(B) Comparison of all S monomers of the three states in ribbon, showing that all “up” RBDs are at the similar orientation while the down RBDs adopt different orientations. The monomers of three states are colored in magenta, blue, and yellow, respectively, VH: variable region of heavy chain; CH: constant region of heavy chain, VL: variable region of light chain; CL: constant region of light chain.

See also Figures S3 and S4 and Table S1.