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. 2023 May 3;42(5):112503. doi: 10.1016/j.celrep.2023.112503

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© 2023 The Author(s)

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Comparison the interface between SARS-CoV-2 wild-type RBD-XG005 and Omicron RBD-XG005

(A) Comparison the models of SARS-CoV-2 wild-type RBD-XG005 and Omicron RBD-XG005. Wild-type RBD and Omicron RBD were shown as ribbons and colored in light sky blue and deep sky blue, respectively. The XG005 IGHV and IGLV are colored in orange and yellow, respectively. Omicron mutation residues located in the XG005 epitope are shown as atoms and colored in magenta.

(B) The model of Omicron RBD-XG005. Omicron RBD is displayed in deep sky blue. The XG005 epitope is colored in orange, and Omicron mutation residues within the interface located in XG005 epitope are shown as atoms and colored in magenta.

(C and D) The detailed interfaces between SARS-CoV-2 wild-type RBD and XG005 (C) and between Omicron RBD and XG005 (D). The red arrows emphasize the specific interactions between RBD and XG005.

(E) Density maps of residues around the wild-type RBD-XG005 interface or Omicron RBD-XG005 interface. Density maps were generated by DeepEMhancer. The Omicron mutations located in the XG005 epitope are labeled.