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. 2023 May 3;42(5):112503. doi: 10.1016/j.celrep.2023.112503

Figure 6.

Figure 6

Structural comparison of XG005 family members revealed the key somatic mutations for broad and potent neutralization

(A) Structural comparison of XG005 (red ribbon), XG005a (yellow ribbon), XG005b (cyan ribbon), and XG005c (blue ribbon). The structural models of XG005a, XG005b, and XG005c were generated by SWISS-MODEL. The residues involved in RBD binding are shown in sticks. The residues that might disturb the interactions between the RBD and Fabs are emphasized by dashed squares.

(B) The interfaces between Omicron RBD (deep sky blue ribbon) and XG005/XG005a/XG005b/XG005c. The distinct key residues among XG005, XG005a, XG005b, and XG005c were labeled. Hydrogen bonds are shown as black dashed lines. Red dashed circle highlights the clash between the Omicron RBD and D31 of XG005a.