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. 2023 Apr 19;14:1102094. doi: 10.3389/fimmu.2023.1102094

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Copyright © 2023 Kuang, Jiang, Zhu, Zhou, Huang, Li, Zhang, Li and Cao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Construction and verification of the ICD risk signature. (A) Univariate Cox regression models identified 17 ICD-related genes associated with overall survival (OS). (B) Through LASSO Cox regression analysis, nine prognostic ICD-related genes were identified in the TCGA queue. (C) Distribution map of the risk score, individual case survival information, and a clustering heatmap of mRNA expression profiles of the nine signature genes in the TCGA cohort. (D) Kaplan-Meier (KM) curves for the OS of LGG patients in the low- and high-risk subclasses in the TCGA queue. (E) Likewise, the KM curves for OS in the CGGA queue.