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. 2023 Apr 19;14:1171931. doi: 10.3389/fphar.2023.1171931

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Copyright © 2023 Makhija, Griffett, Veerakanellore, Burris, Elgendy and Griffett.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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In vitro model of REV-ERB anti-inflammatory actions. (A) Mouse bone marrow-derived macrophages from Nr1d1 ^−/− (n = 7) and wildtype (n = 12) mice. Both male and female mice were used for this study and no sex-specific differences were noted. (B) IL-1β ELISA results for differentiated Thp-1 cells. (C) NLRP3gene expression results of the differentiated Thp-1 cells. Results were graphed and analyzed in Graphpad Prism by ANOVA and represented as Mean ± SEM.