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. 2023 Apr 19;14:1148877. doi: 10.3389/fimmu.2023.1148877

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Copyright © 2023 Nantambi, Sembera, Ankunda, Ssali, Kalyebi, Oluka, Kato, Ubaldo, Kibengo, Katende, Gombe, Baine, Odoch, Mugaba, Sande, The COVID-19 Immunoprofiling Team, Kaleebu and Serwanga

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pre-epidemic IFN-γ responses to SAR-CoV-2, HCoV-229E and HCoV-OC43. Illustrates the virus-specific IFN-γ responses to 18 SARS-CoV-2 and two human coronavirus peptide pools (HuCoVOC43 and HuCoV229E). IFN-γ response magnitudes are depicted and quantified as spot-forming units per million PBMC cells. The horizontal dotted red line represents the cut-off threshold for a positive response of 55 SFU/million PBMCs (A). The data represents 104 pre-COVID specimens classified as positive in red and negative in blue based on HIV serostatus (B).