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. 2023 Apr 19;14:1180404. doi: 10.3389/fendo.2023.1180404

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Copyright © 2023 Zhao, Wang, Ding, Ye, Cheng, Shao, Liu and Zhou

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Transcriptional alterations and expression of DRG in BLCA. (A) Location of CNV alterations in DRG on chromosome 23. (B) Frequency of mutations in the 4 DRGs in 414 BLCA patients from the TCGA cohort. (C) Correlation of 4 DRG expressions. (D) Correlation of cibersort results showing expression of the 4 DRGs with immune cell infiltration. (E) IHC staining of SLC3A2 and RPN1 expression in normal tissue, Non-MIBC, and MIBC samples (at 20× magnification, scale bar, 50μm). MIBC Muscle invasive bladder cancer; *p<0.05; **p<0.01; ***p<0.001.