Table 3.

Concentrations of EVG, TAF and TFV (ng/mL) in vaginal fluid.

Analyte	Visit	Statistical Measures *	Group 1 4 hours at Visit 3 and 48 hours at Visit 4 (N=8)	Group 2 24 hours at Visit 3 and 72 hours at Visit 4 (N=8)
EVG (ng/mL) vaginal fluid	Visit 3	n	8	7
		Mean (SD)	2,201,502 (1,741,831)	323,378 (278,363)
		Median (Q1, Q3)	1,507,362 (1,054,818, 2,802,391)	177,765 (95,935, 649,951)
		Number (%) with BLQ	0 (0.0%)	0 (0.0%)
	Visit 4	n	8	7
		Mean (SD)	25,668 (14,044)	31,204 (52,647)
		Median (Q1, Q3)	26,090 (16,037, 33,252)	4,816 (1,535, 65,403)
		Number (%) with BLQ	0 (0.0%)	0 (0.0%)
	Visit 5	n	8	8
	[7 days post-dose]	Mean (SD)	923 (1,915)	1,804 (2,453)
		Median (Q1, Q3)	199 (37, 657)	376 (38, 3,556)
		Number (%) with BLQ	0 (0.0%)	1 (12.5%)
TAF (ng/mL) vaginal fluid	Visit 3	n	8	7
		Mean (SD)	3,662,350 (4,966,790)	368,539 (251,283)
		Median (Q1, Q3)	2,319,007 (1,267,333, 3,249,263)	340,854 (232,508, 474,736)
		Number (%) with BLQ	0 (0.0%)	0 (0.0%)
	Visit 4	n	8	7
		Mean (SD)	12,471 (15,094)	5,380 (6,788)
		Median (Q1, Q3)	4,278 (122, 27,786)	953 (16, 13,608)
		Number (%) with BLQ	0 (0.0%)	1 (14.3%)
	Visit 5	n	8	8
	[7 days post-dose]	Mean (SD)	10 (17)	22 (51)
		Median (Q1, Q3)	0.76 (0.01, 19.06)	0.79 (0.01, 13.50)
		Number (%) with BLQ	4 (50.0%)	3 (37.5%)
TFV (ng/mL) vaginal fluid	Visit 3	n	8	7
		Mean (SD)	241,795 (155,893)	227,198 (174,859)
		Median (Q1, Q3)	227,644 (142,779, 332,234)	210,543 (60,496, 342,268)
		Number (%) with BLQ	0 (0.0%)	0 (0.0%)
	Visit 4	n	8	7
		Mean (SD)	28,511 (19,961)	21,674 (18,390)
		Median (Q1, Q3)	19,961 (14,608, 37,790)	17,098 (9,004, 28,946)
		Number (%) with BLQ	0 (0.0%)	0 (0.0%)
	Visit 5:	n	8	8
	[7 days post-dose]	Mean (SD)	4,353 (3,645)	2,919 (2,386)
		Median (Q1, Q3)	3,592 (2,484, 4,668)	2,651 (1,052, 4,059)
		Number (%) with BLQ	0 (0.0%)	0 (0.0%)

*Means and Medians do not include BLQ values.