Table 4.
Concentrations of EVG, TAF and TFV (ng/mg) and TFV-DP (fmol/mg) in vaginal tissue.
| Analyte | Visit | Statistical Measures* | Group 1 4 hours at Visit 3 and 48 Hours at Visit 4 (N=8) |
Group 2 24 hours at Visit 3 and 72 Hours at Visit 4 (N=8) |
|---|---|---|---|---|
| EVG (ng/mg) | Visit 3 | n | 8 | 7 |
| Mean (SD) | 20.64 (15.11) | 25.43 (23.57) | ||
| Median (Q1, Q3) | 17.75 (14.90, 20.03) | 15.79 (2.84, 49.13) | ||
| Number (%) with BLQ | 0 (0.0%) | 0 (0.0%) | ||
| Visit 4 | n | 8 | 7 | |
| Mean (SD) | 1.60 (2.10) | 1.05 (1.19) | ||
| Median (Q1, Q3) | 0.60 (0.27, 2.43) | 0.62 (0.30, 1.67) | ||
| Number (%) with BLQ | 0 (0.0%) | 0 (0.0%) | ||
| TAF (ng/mg) | Visit 3 | n | 8 | 7 |
| Mean (SD) | 69.15 (85.49) | 22.78 (28.15) | ||
| Median (Q1, Q3) | 42.87 (1.05, 112.99) | 11.92 (0.41, 59.25) | ||
| Number (%) with BLQ | 0 (0.0%) | 0 (0.0%) | ||
| Visit 4 | n | 8 | 7 | |
| Mean (SD) | 0.15 (0.200) | 0.48 (0.611) | ||
| Median (Q1, Q3) | 0.05 (0.02, 0.23) | 0.01 (0.00, 0.98) | ||
| Number (%) with BLQ | 4 (50.0%) | 4 (57.1%) | ||
| TFV (ng/mg) | Visit 3 | n | 8 | 7 |
| Mean (SD) | 8.77 (7.378) | 29.69 (25.049) | ||
| Median (Q1, Q3) | 5.42 (3.73, 12.67) | 31.38 (6.64, 56.15) | ||
| Number (%) with BLQ | 0 (0.0%) | 0 (0.0%) | ||
| Visit 4 | n | 8 | 7 | |
| Mean (SD) | 9.61 (8.092) | 6.66 (5.222) | ||
| Median (Q1, Q3) | 5.99 (3.27, 17.63) | 4.51 (2.38, 11.95) | ||
| Number (%) with BLQ | 0 (0.0%) | 0 (0.0%) | ||
| TFV-DP (fmol/mg) | Visit 3 | n | 8 | 7 |
| Mean (SD) | 222.13 (256.72) | 3642.08 (5557.17) | ||
| Median (Q1, Q3) | 156.80 (50.66, 257.97) | 2040.79 (489.56, 3022.31) | ||
| Number (%) with BLQ | 0 (0.0%) | 0 (0.0%) | ||
| Visit 4 | n | 8 | 7 | |
| Mean (SD) | 5325.38 (5795.41) | 2161.36 (2410.96) | ||
| Median (Q1, Q3) | 1934.10 (741.09, 11627.59) | 1291.08 (888.06, 2875.39) | ||
| Number (%) with BLQ | 0 (0.0%) | 0 (0.0%) |
*Means and Medians do not include BLQ values.