Table 1.
Newly identified adipose tissue subtypes.
| Macrophages phenotype | Category | Location | Marker | Function | Reference |
|---|---|---|---|---|---|
| MMe (metabolically activated macrophages) | Recruited macrophages | CLS | ABCA1, CD36, PLIN2 | Removing dead adipocytes through lysosomal exocytosis | (61) (62) (63) |
| CD9+ macrophages | Recruited macrophages | CLS | CD9, LPL, PLIN2, CD63, LAMP2, CD16, CD206 | Promotion of obesity | (64) |
| LAM (lipid-associated macrophages) | Recruited macrophages | CLS | TREM2, LIPA, LPL, CTSB, CTSL, FABP4, FABP5, LGALS1, LGALS3, CD9, CD36 | Preventing metabolic disorders when adipocyte homeostasis is lost | (65) |
| DARC+ macrophages | Recruited macrophages | CLS | DARC, Ly6C(low), M2-related marker(high) | Anti-inflammation and reducing immune cell infiltration. | (66) |
| MFehi macrophages | Resident macrophages | Intercellular space; CLS (a small number) |
CD163, TFRC, HO-1, FTL1, FTH1, CP, SLC40A1, F4/80, CD11c(high), CD206(low) | Coping with iron metabolic disorders | (67) (68) |