Table 1.
Studies involving schistosome single-sex infections in the last 30 years.
| Year | Natural/ Artificial |
Species | Main content | Reference |
|---|---|---|---|---|
| 1993 | Natural | S. mansoni | Distribution of SF and SM within the host population | (18) |
| 1994 | Artificial | S. japonicum | Circulating antigen detection of SF and SM infection | (19) |
| 1994 | Artificial |
S. mansoni &
S. intercalatum |
Single-sex schistosomes mated with the opposite sexes of heterologous species | (21) |
| 1995 | Artificial |
S. mansoni &
S. haematobium |
Single-sex schistosomes mated with the opposite sexes of heterologous species | (20) |
| 1995 | Artificial |
S. mansoni &
S. intercalatum |
Mating competition between males | (22) |
| 1999 | Artificial |
S. mansoni &
S. haematobium |
Single-sex schistosomes mated with the opposite sexes of heterologous species | (25) |
| 2001 | Artificial | S. mansoni | PCR for sexing cercariae | (43) |
| 2002 | Natural | S. mansoni | Single-sex infected snails found in the field | (33) |
| 2002 | Artificial |
Schistosoma mansoni &
S. margrebowiei |
Single-sex schistosomes mated with the opposite sexes of heterologous species | (23) |
| 2003 | Artificial |
S. mansoni &
S. intercalatum |
Single-sex schistosomes mated with the opposite sexes of heterologous species | (24) |
| 2004 | Artificial | S. mansoni | Morphological observation of SF and MF | (38) |
| 2006 | Artificial | S. mansoni | Transcriptional analysis of 49-day SF and SM | (73) |
| 2012 | Artificial | S. mansoni | Transcriptional analysis of 49-day SF and MF | (29) |
| 2012 | Natural | S. japonicum | Single-sex infected schistosomes found in surveillance | (15) |
| 2014 | Natural | S. japonicum | Single-sex infected snails found in the field | (32) |
| 2014 | Artificial | S. japonicum | MicroRNA profiles of 18- and 23-day SF and MF | (71) |
| 2016 | Artificial | S. mansoni | Transcriptional analysis of 67-day SF and SM | (47) |
| 2017 | Artificial | S. mansoni | Profiles of sma-mir-277/4989 and its target genes | (74) |
| 2017 | Artificial | S. mansoni | SF mitigates liver fibrosis after secondary infection | (75) |
| 2018 | Artificial | S. mansoni | Transcriptional analysis of all life stages of SF and SM | (51) |
| 2018 | / | / | Opinion article regarding the importance of single-sex infection | (11) |
| 2018 | Artificial | S. mansoni | Immunoregulation of SF and SM | (76) |
| 2019 | Artificial | S. mansoni | SF mitigates liver fibrosis after secondary infection | (77) |
| 2020 | Artificial | S. japonicum | Duplex RT-PCR for sexing cercariae | (42) |
| 2020 | Artificial | S. japonicum | Proteomic profiles of 25-day SF and MF | (45) |
| 2020 | Artificial | S. japonicum | MicroRNA profiles of 25-day SF and MF | (72) |
| 2020 | Artificial | S. mansoni | Single-cell RNA-seq analysis of 6–7 weeks SF and MF | (53) |
| 2021 | Artificial | S. japonicum | Survival and reproductive potential of SF and SM | (17) |
| 2022 | Artificial | S. mansoni | CCA and CAA of SF and SM | (12) |
| 2022 | Artificial | S. japonicum | Proteomic profiles of 18-, 21-, 23-, 25-day SF and MF | (37) |
| 2022 | Artificial | S. japonicum | Proteomic profiles of 18-, 21-, 23-, 25-day SM and MM | (16) |
| 2022 | Artificial | S. japonicum | PZQ treatment of SF and SM | (26) |
| 2022 | Artificial | S. mansoni | Transcriptional analysis of host infected with SF and SM | (78) |
| 2022 | Artificial | S. mansoni | BATT from male worms stimulate SF to develop | (79) |
| 2023 | Artificial | S. japonicum | Functional analysis of DEPs coming from SF and MF | (61) |
| 2023 | Artificial | S. mansoni | Single-sex infection boost immune response | (80) |
SF, single-sex female worms; SM, single-sex male worms; MF, bisexual mated female worms; MM, bisexual mated male worms; PCR, polymerase chain reaction; RT-PCR, real-time polymerase chain reaction; CCA, circulating cathodic antigen; CAA, circulating anodic antigen; PZQ, praziquantel; BATT, β-alanyl-tryptamine; DEP, differentially expressed protein. /, not applicable.