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. 2023 Apr 19;14:1177722. doi: 10.3389/fimmu.2023.1177722

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Copyright © 2023 Solé, Parras, Yamanouchi, Garnica, Garabatos, Moro, Montaño, Mondal, Fandos, Yang, Serra and Santamaria

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cluster distribution of repeated clonotypic TCRαβ pairs within tetramer+ cells of pMHCII-NP-treated mice. (A) Seurat clustering analysis of SMARTseq2-based scRNAseq data for sorted tetramer+ and tetramer– cells from NOD mice treated with BDC2.5mi/IA^g7- or InsB_9-23/IA^g7-NPs (from n=5 and 15 mice, respectively). Most tetramer+ cells (63.6%) are found in cluster #2 (TR1-like). (B) Sub-cluster distribution of each of the repeated clonotypic TCRαβ pairs (found in more than one cell) for tetramer+ cells from NOD mice treated with BDC2.5mi/IA^g7- or InsB_9-23/IA^g7-NPs. (C) Pie chart displaying the percentage of repeated clonotypes shared by clusters #1 and #2 or expressed only by clusters #1 or #2 among all clonotypes identified, as well as the number of cells expressing these clonotypes among all cells analyzed.