Table 3.
Differentially expressed markers in treatment versus control groups.
| Gene | Insulin treatments vs. control | BDC vs. Control (Ins Tet–) |
BDC vs. Insulin treatments | |||
|---|---|---|---|---|---|---|
| logFC | padj | logFC | padj | logFC | padj | |
| Pdcd1 | 3.42 | 1.7E-30 | 2.209 | 2.6E-25 | -1.407 | 0.03062 |
| Nt5e | 3.141 | 7.3E-18 | 2.693 | 1.3E-24 | -0.462 | 1 |
| Gzmb | 3.034 | 1 | -0.044 | 1 | -3.046 | 0.1178 |
| Cxcr5 | 2.989 | 2.7E-22 | -0.583 | 2.1E-18 | -3.189 | 0.11131 |
| Il10 | 2.865 | 1.5E-05 | 4.601 | 1.9E-43 | 2.665 | 5.4E-27 |
| Nfil3 | 2.75 | 9.5E-07 | 3.617 | 3.3E-32 | 1.469 | 2.6E-13 |
| Ifng | 2.704 | 2.5E-12 | 3.233 | 1.4E-25 | 0.724 | 1 |
| Il21 | 2.703 | 2E-17 | 2.156 | 3E-23 | -0.673 | 1 |
| Tigit | 2.636 | 9.2E-24 | 3.068 | 8.6E-42 | 0.812 | 9.6E-08 |
| Lag3 | 2.507 | 2E-13 | 2.291 | 1.6E-25 | -0.186 | 1 |
| Ascl2 | 2.445 | 1.6E-12 | 1.067 | 3.5E-13 | -1.489 | 1 |
| Prdm1 | 2.352 | 1 | 2.451 | 1.7E-08 | 0.125 | 1 |
| Il10Ra | 2.331 | 1 | 1.502 | 0.00015 | -0.33 | 1 |
| Entpd1 | 2.331 | 1 | 2.618 | 1.1E-09 | 0.368 | 1 |
| Tox2 | 2.181 | 1.3E-16 | 1.747 | 2.7E-19 | -0.618 | 1 |
| Tbx21 | 1.825 | 1 | 1.798 | 0.33849 | 0.118 | 1 |
| Bcl6 | 1.811 | 6.8E-21 | 0.952 | 3.8E-20 | -0.821 | 1 |
| Maf | 1.764 | 1.6E-14 | 2.144 | 9.1E-26 | 0.347 | 1 |
| Rbpj | 1.76 | 1.6E-05 | 1.447 | 5.9E-09 | -0.266 | 1 |
| Serpinb9 | 1.752 | 1 | ND | ND | -1.672 | 0.00162 |
| Cxcr3 | 1.697 | 6.8E-15 | 0.456 | 1.3E-20 | -1.295 | 1 |
| Il4 | 1.686 | 1.4E-07 | -0.204 | 0.00331 | -1.732 | 1 |
| Ctla4 | 1.665 | 1E-13 | 2.857 | 8.1E-49 | 1.253 | 5.1E-22 |
| Tgfbr1 | 1.619 | 1 | -0.088 | 1 | -0.595 | 1 |
| Ebi3 | 1.57 | 1 | ND | ND | -1.53 | 0.00203 |
| S1pr2 | 1.518 | 1 | ND | ND | -1.454 | 0.00019 |
| Icos | 1.21 | 1.2E-18 | 1.676 | 4.9E-27 | 0.451 | 0.00121 |
| Cd226 | 1.141 | 1.3E-13 | 0.658 | 5.4E-21 | -0.479 | 1 |
| Nfia | 1.096 | 0.08018 | 1.429 | 8.7E-06 | 0.351 | 1 |
| Cbfa2t3 | 1.059 | 1 | -0.049 | 1 | -1.08 | 1 |
| Stat3 | 0.996 | 1.3E-13 | 0.994 | 4.9E-20 | 0.013 | 1 |
| Batf | 0.976 | 1.5E-15 | 0.649 | 2.6E-19 | -0.394 | 1 |
| Id2 | 0.899 | 3.6E-12 | 1.078 | 7.9E-22 | 0.166 | 1 |
| Cd28 | 0.849 | 7.2E-15 | 1.283 | 1.1E-19 | 0.384 | 0.01741 |
| Tnfrsf4 | 0.845 | 3.1E-13 | 1.734 | 2.6E-43 | 0.884 | 5.6E-14 |
| Irf1 | 0.654 | 1E-14 | 0.795 | 1.4E-22 | 0.04 | 1 |
| Tnfrsf18 | 0.629 | 2.1E-09 | 0.759 | 2.5E-15 | 0.124 | 1 |
| Sh2d1a | 0.514 | 3.1E-11 | -0.461 | 4.4E-17 | -0.909 | 1 |
| Il21r | 0.489 | 1.7E-12 | 0.863 | 7.3E-18 | 0.366 | 1 |
| Il27ra | 0.482 | 9.5E-08 | -0.397 | 3.3E-19 | -0.872 | 1 |
| Stat4 | 0.458 | 6.8E-11 | 0.541 | 6.5E-17 | 0.038 | 1 |
| Tgfbr2 | 0.441 | 1.1E-15 | 0.211 | 3E-18 | -0.265 | 1 |
| Hmgb2 | 0.368 | 8.9E-10 | 0.752 | 1.2E-16 | 0.354 | 1 |
| Elk4 | 0.349 | 2.4E-11 | 0.45 | 3.8E-17 | 0.083 | 1 |
| Itk | 0.341 | 1.2E-13 | 0.549 | 1.2E-17 | 0.116 | 1 |
| Tcf7 | 0.313 | 5.7E-14 | 0.171 | 2.4E-16 | -0.155 | 1 |
| Cxcr4 | 0.267 | 1.8E-13 | 2.022 | 2.2E-32 | 2.007 | 2.3E-44 |
| Cblb | 0.255 | 5.6E-11 | 1.342 | 7.7E-23 | 1.039 | 1.5E-08 |
| Id3 | 0.237 | 5.9E-18 | -1.576 | 8.8E-26 | -1.678 | 1 |
| Cd40lg | 0.163 | 4.7E-12 | -0.341 | 1.3E-19 | -0.475 | 1 |
| Stat1 | -0.1 | 8.7E-09 | -0.506 | 3.3E-11 | -0.424 | 1 |
| Selplg | -0.368 | 2.1E-10 | -1.124 | 5.5E-18 | -0.762 | 1 |
| Rora | -0.401 | 8.2E-08 | 0.459 | 1.7E-16 | 0.887 | 0.00035 |
| Foxp1 | -0.404 | 1.3E-09 | -0.487 | 1.3E-15 | -0.098 | 1 |
| Il2ra | -0.627 | 5.8E-07 | -0.93 | 1.6E-09 | -0.227 | 1 |
| Foxp3 | -0.692 | 5.5E-11 | -3.151 | 5.6E-12 | -1.972 | 1 |
| Bmyc | -0.723 | 6.4E-10 | -1.812 | 1.2E-11 | -0.826 | 1 |
| S1pr1 | -0.87 | 1.7E-20 | -0.293 | 6.1E-09 | 0.604 | 0.36342 |
| Il7r | -1.415 | 4.8E-19 | -1.002 | 7.5E-22 | 0.349 | 1 |
| Ccr7 | -1.549 | 1E-22 | 0.249 | 5.4E-13 | 1.737 | 2.5E-19 |
| Lef1 | -1.607 | 2.7E-28 | -1.505 | 3.8E-27 | 0.161 | 1 |
| Klf2 | -2.667 | 6.6E-19 | -0.324 | 1.3E-13 | 2.208 | 5.4E-10 |
| Myc | -3.455 | 1.3E-15 | -1.981 | 2.4E-11 | 1.547 | 0.00365 |
| Sell | -4.367 | 1.1E-35 | -1.197 | 5E-25 | 3.08 | 1.4E-08 |
FC, fold change; Padj, adjusted P value; ND, not detected.