Table 1.
Demographics
| SCZ (n = 389) | AFF (n = 178) | HC (418) | P | SCZ vs HC | AFF vs HC | SCZ vs AFF | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| n | Mean (SD) | n | Mean (SD) | n | Mean (SD) | P | P | P | ||
| Age, yrs | 389 | 29.2 (9.4) | 178 | 33 (12.2) | 418 | 31.9 (8.6) | 7.3E−081 | 1.7E−053 | 0.2443 | 6.6E−053 |
| Sex (male) | 241 | 61.9 % | 80 | 44.9 % | 244 | 58.4 % | .0012 | .2992 | .0032 | 1.5E−042 |
| PANSS total | 376 | 54.8 (17) | 177 | 41.2 (12) | – | – | – | – | – | 2.7E−073 |
| YMRS | 278 | 10.8 (10.3) | 167 | 10.3 (9.5) | – | – | – | – | – | .6093 |
| GAF-S | 388 | 28.6 (11.5) | 178 | 39.4 (12.7) | – | – | – | – | – | <2E−163 |
| BMI, kg/m2 | 357 | 26.4 (5.1) | 168 | 25.2 (4.2) | 368 | 24.5 (3.5) | 2.1E−121 | 3E−093 | .0333 | .0083 |
| CRP, mg/L | 389 | 3.2 (2.7) | 178 | 2.6 (2.5) | 418 | 2.3 (2.2) | .0011 | 5.4E−073 | .2533 | .0083 |
| Antipsychotics use | 321 | 82.5% | 105 | 58.9% | 0 | 0.0% | – | – | – | 1.8E−092 |
| DDD antipsychotics | 317 | 1.3 (0.9) | 105 | 0.9 (0.8) | – | – | – | – | – | .0013 |
| Anti-epileptics use | 40 | 10.3% | 73 | 41% | 0 | 0.0% | – | – | – | 1.9E−172 |
| DDD anti-epileptics | 40 | 0.6 (0.4) | 72 | 0.9 (0.5) | – | – | – | – | – | .0033 |
| Antidepressants use | 114 | 29.3% | 66 | 37.1% | 0 | 0.0% | – | – | – | .0642 |
| DDD antidepressants use | 106 | 1.7 (0.9) | 59 | 1.4 (0.8) | – | – | – | – | – | .0513 |
Categorical data are given as percentage while continuous data are given as mean (SD).
HC, healthy controls; SCZ, Schizophrenia; AFF, affective disorders; BMI, body mass index; PANSS, Positive and Negative Syndrome Scale; YMRS, Young Mania Rating Scale; GAF-S, Global Assessment of Functioning Scale; CRP, C-reactive protein.
1One-way ANOVA.
2Chi-square test.
3Scheffe’s post hoc test.