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(A) Representative 1H-MRS PRESS voxel (red; inner rectangle) and corresponding shim (green; outer rectangle) placement in ventral hippocampus (left) and 1H-MRS spectrum (right). (B) Z-scores of 1H-MRS metabolites in the ventral hippocampus. Glutamine was significantly higher in Lhx6-Cre;Erbb4F/F mutant mice (n = 12, 9 female, 3 male) compared to control mice (n = 12, 5 female, 7 male; Pcorr < .001, d = 1.96). GABA: gamma-aminobutyric acid; Glu: glutamate; Gln: glutamine.
