Table 3.
Altered Metabolites and Associated Metabolic Pathways in AP-Induced Constipation
| Metabolites | Metabolic pathway | Retention time/min | m/z | VIP | P value | FC value |
|---|---|---|---|---|---|---|
| Sphingosine-1-phosphate | Sphingolipid metabolism, sphingolipid signaling pathway | 7.01 | 378.24 | 1.61 | .001 | 0.83 ↓ |
| Phytosphingosine | Sphingolipid metabolism | 6.28 | 318.3 | 1.79 | .01 | 0.90 ↓ |
| Sphinganine | Sphingolipid metabolism, sphingolipid signaling pathway | 6.77 | 302.31 | 1.32 | .0001 | 0.80 ↓ |
| Phosphatidylcholine | ||||||
| PC(14:1(9Z)/20:1(11Z)) | Choline metabolism in cancer | 9.72 | 780.55 | 4.54 | 0.04 | 0.90 ↓ |
| PC(18:1(11Z)/18:0) | 11.57 | 810.60 | 7.92 | 0.004 | 1.15 ↑ | |
| PC(16:0/20:4(8Z,11Z,14Z,17Z)) | 8.26 | 826.56 | 7.38 | 0.01 | 1.10 ↑ | |
| PC(20:1(11Z)/18:3(6Z,9Z,12Z)) | 8.28 | 854.59 | 8.64 | 0.01 | 1.10 ↑ | |
| Lysophosphatidylcholines | ||||||
| LysoPC(18:0) | Choline metabolism in cancer | 8.34 | 568.36 | 11.6 | .04 | 0.93 ↓ |
| LysoPC(17:0) | 8.34 | 508.34 | 7.89 | .04 | 0.93 ↓ | |
| LysoPC(22:4(7Z,10Z,13Z,16Z)) | 7.84 | 616.36 | 1.24 | .03 | 1.21 ↑ | |
| LysoPC(20:2(11Z,14Z)) | 8.45 | 548.37 | 2.23 | .03 | 1.15 ↑ | |
Note: ↑ and ↓ signs indicate upregulated and downregulated metabolites, respectively.