Table 1.
Reported GPCR structures
| Class | Receptors | Total number | PDB ID (receptor alone) | PDB ID (G protein coupled receptor) |
|---|---|---|---|---|
| A | ADRB3 | 1 | 7DH5 | |
| AGTR1 | 6 | 6OS0, 6OS1, 6OS2, 6DO1, 4ZUD, 4YAY | ||
| AGTR2 | 7 | 7JNI, 7C6A, 6JOD, 5XJM, 5UNH, 5UNG, 5UNM | ||
| HTR1A | 3 | 7E2X, 7E2Y, 7E2Z | ||
| HTR1B | 5 | 7C61, 5V54, 4IAR, 4IAQ | 6G79 | |
| HTR1D | 1 | 7E32 | ||
| HTR1E | 1 | 7E33 | ||
| HTR1F | 1 | 7EXD | ||
| HTR2A | 13 | 7WC4, 7WC5, 7WC6, 7WC7, 7WC8, 7WC9, 7VOD, 7VOE, 6WGT, 6WH4, 6A94, 6A93 | 6WHA | |
| HTR2B | 8 | 6DRY, 6DS0, 6DRZ, 6DRX, 5TUD, 5TVN, 4NC3, 4IB4 | ||
| HTR2C | 2 | 6BQG, 6BQH | ||
| ACM1 | 6 | 6ZFZ, 6ZG9, 6ZG4, 6WJC, 5CXV | 6OIJ | |
| ACM2 | 10 | 5ZKB, 5ZKC, 5ZK3, 5ZK8, 5YC8, 4MQT, 4MQS, 3UON | 6U1N, 6OIK | |
| ACM3 | 5 | 5ZHP, 4U14, 4U15, 4U16, 4DAJ | ||
| ACM4 | 2 | 6KP6, 5DSG | ||
| ACM5 | 1 | 6OL9 | ||
| APJ | 2 | 6KNM, 5VBL | ||
| BKRB1 | 1 | 7EIB | ||
| BKRB2 | 1 | 7F2O | ||
| C5AR1 | 3 | 6C1Q, 6C1R, 5O9H | ||
| CCKAR | 8 | 7F8X, 7F8U, 7F8Y | 7EZM, 7EZH, 7EZK, 7MBX, 7MBY | |
| CCR1 | 3 | 7VLA, 7VL8, 7VL9 | ||
| CCR2 | 3 | 6GPS, 6GPX, 5T1A | ||
| CCR5 | 11 | 7F1T, 6MET, 6MEO, 6AKY, 6AKX, 5UIW, 4MBS | 7F1Q, 7F1R, 7F1S, 7O7F | |
| CCR6 | 1 | 6WWZ | ||
| CCR7 | 1 | 6QZH | ||
| CCR9 | 1 | 5LWE | ||
| CNR1 | 8 | 7V3Z, 6KQI, 5XRA, 5XR8, 5U09, 5TGZ | 6KPG, 6N4B | |
| CNR2 | 4 | 6KPC, 5ZTY | 6KPF, 6PT0 | |
| CXCR2 | 3 | 6LFL | 6LFM, 6LFO | |
| CXC-R4 | 6 | 4RWS, 3ODU, 3OE0, 3OE6, 3OE8, 3OE9 | ||
| DRD1 | 11 | 7JOZ, 7CKW, 7CKX, 7CKY, 7CKZ, 7CRH, 7LJC, 7LJD, 7JV5, 7JVP, 7JVQ | ||
| DRD2 | 5 | 7DFP, 6LUQ, 6CM4 | 7JVR, 6VMS | |
| DRD3 | 3 | 3PBL | 7CMV, 7CMU | |
| DRD4 | 3 | 6IQL, 5WIV, 5WIU | ||
| EDNRB | 8 | 6LRY, 6K1Q, 6IGL, 6IGK, 5XPR, 5X93, 5GLH, 5GLI | ||
| FFAR1 | 4 | 5KW2, 5TZY, 5TZR, 4PHU | ||
| FPR1 | 2 | 7WVU, 7T6T | ||
| FPR2 | 9 | 6LW5 | 7WVV, 7WVX, 7WVW, 7WVY, 7T6V, 7T6S, 7T6U, 6OMM | |
| GALR1 | 1 | 7WQ3 | ||
| GALR2 | 1 | 7WQ4 | ||
| CCKBR | 2 | 7F8V, 7F8W | ||
| GHSR | 7 | 7F83, 6KO5 | 7W2Z, 7NA7, 7NA8, 7F9Y, 7F9Z | |
| GNRHR | 1 | 7BR3 | ||
| GPBAR1 | 3 | 7CFM,7CFN, 7BW0 | ||
| HRH1 | 2 | 3RZE | 7DFL | |
| LPAR1 | 6 | 4Z34, 4Z35, 4Z36 | 7TD0, 7TD1, 7TD2 | |
| LSHR | 4 | 7FIJ | 7FIG, 7FII, 7FIH | |
| LT4R1 | 2 | 7K15 | 7VKT | |
| MC4R | 8 | 6W25 | 7PIV, 7PIU, 7F53, 7F54, 7F55, 7F58, 7AUE | |
| MSHR | 4 | 7F4D, 7F4H, 7F4I, 7F4I | ||
| MTNR1A | 8 | 6PS8, 6ME2, 6ME3, 6ME4, 6ME5 | 7VGY, 7VGZ, 7DB6 | |
| MTNR1B | 5 | 6ME6, 6ME7, 6ME8, 6ME9 | 7VH0 | |
| NK1R | 11 | 6J20, 6J21, 6HLP, 6HLL, 6HLO, 6E59 | 7P00, 7P02, 7RMI, 7RMG, 7RMH | |
| NPY1R | 3 | 5ZBH, 5ZBQ | 7VGX | |
| NPY2R | 1 | 7DDZ | ||
| NTSR1 | 24 | 6YVR, 6Z4Q, 6Z4S, 6Z4V, 6Z66, 6Z8N, etc | 7L0P, 7L0Q, 7L0R, 7L0S, 6UP7, 6PWC, 6OSA, 6OS9 | |
| OPRD | 6 | 6PT2, 6PT3, 4RWD, 4RWA, 4N6H, 4EJ4 | ||
| OPRK | 3 | 6VI4, 6B73, 4DJH | ||
| OPRM | 7 | 5C1M, 4DKL | 7U2L, 7SBF, 7SCG, 6DDF, 6DDE | |
| OPRL1 | 3 | 5DHG, 5DHH, 4EA3 | ||
| HCRTR1 | 14 | 6V9S, 6TOT, 6TOS, 6TOD, 6TQ4, 6TP4, etc | ||
| HCRTR2 | 8 | 6TPG, 6TPJ, 6TPN, 5WS3, 5WQC, 4S0V | 7L1U, 7L1V | |
| OXYR | 2 | 6TPK | 7RYC | |
| P2RY1 | 2 | 4XNV, 4XNW | ||
| P2Y12 | 3 | 4PXZ, 4PY0, 4NTJ | ||
| PAR1 | 1 | 3VW7 | ||
| PAR2 | 3 | 5NDZ, 5NJ6, 5NDD | ||
| PTGDR2 | 3 | 7M8W, 6D26, 6D27 | ||
| PTGER2 | 3 | 7CX2, 7CX3, 7CX4 | ||
| PTGER3 | 2 | 6AK3, 6M9T | ||
| PTGER4 | 3 | 5YHL, 5YWY | 7D7M | |
| PTAFR | 2 | 5ZKQ, 5ZKP | ||
| lpar6a | 1 | 5XSZ | ||
| BLT1 | 1 | 5X33 | ||
| S1PR1 | 11 | 3V2W, 3V2Y | 7TD4, 7TD3, 7EO4, 7EO2, 7EVY, 7WF7, 7EW0, 7EW7, 7EVZ | |
| S1PR2 | 1 | 7T6B | ||
| S1PR3 | 4 | 7C4S | 7EW2, 7EW3, 7EW4 | |
| S1PR5 | 1 | 7EW1 | ||
| SSR2 | 2 | 7T10, 7T11 | ||
| SUCR1 | 3 | 6Z10, 6RNK, 6IBB | ||
| TBXA2R | 2 | 6IIU, 6IIV | ||
| V2R | 2 | 7DW9, 7BB6 | ||
| GPR52 | 4 | 6LI0, 6LI1, 6LI2 | 6LI3 | |
| GPR88 | 2 | 7EJX, 7WZ4 | ||
| GPR139 | 4 | 7VUH, 7VUJ, 7VUI, 7VUY | ||
| GPR183 | 2 | 7TUY | 7TUZ | |
| MRGX2 | 14 | 7VV6, 7VV4, 7VV0 | 7VDM, 7VDH, 7VUZ, 7VDL, 7VV5, 7VUY, 7VV3, 7S8M, 7S8O, 7S8L, 7S8N | |
| MRGX4 | 1 | 7S8P | ||
| B1 | CALCR | 12 | 5UZ7, 6NIY, 7TYL, 7TYI, 7TYN, 7TYO, 7TYF, 7TYW, 7TYH, 7TYX, 7TYY, 7TZF | |
| CALRL | 6 | 7KNU, 7KNT | 6E3Y, 6UVA, 6UUN, 6UUS | |
| CRFR1 | 4 | 4K5Y, 4Z9G | 6PB0, 6P9X | |
| CRFR2 | 1 | 6PB1 | ||
| GHRHR | 2 | 7CZ5, 7V9M | ||
| GIPR | 6 | 7FIY, 7VAB, 7FIN, 7DTY, 7RBT, 7RA3 | ||
| GLP1R | 34 | 5NX2, 5VEW, 5VEX, 6KJV, 6KK1, 6KK7, 6LN2 | 7FIM, 7VBI, 7LLL, 7LLY, 7S1M, 7S3I, 7RTB, 7DUR, 7EVM, 7KI0, 7KI1, 7DUQ, 7E14, 7LCJ, 7LCK, 7LCI, 6XOX, 6X1A, 6X18, 6X19, 7C2E, 6VCB, 6ORV, 6B3J, 7RGP, 7RG9, 7VBH | |
| GLP2R | 1 | 7D68 | ||
| GCGR | 10 | 4L6R, 5EE7, 5XEZ, 5XF1, 5YQZ | 6LMK, 6LML, 6WHC, 6WPW, 7V35 | |
| SCTR | 3 | 6WZG, 6WI9, 7D3S | ||
| B2 | ADGRG1 | 1 | 7SF8 | |
| ADGRL3 | 1 | 7SF7 | ||
| C | GABBR1 | 1 | 6W2Y | |
| GABBR2 | 12 | 7C7S, 7C7Q, 6UO8, 6VJM, 6UOA, 6UO9, 6W2X, 6WIV, 7CUM, 7CA5, 7CA3 | 7EB2 | |
| GRM1 | 3 | 4OR2, 7DGE, 7DGD, | ||
| GRM2 | 9 | 7MTR, 7MTQ, 7EPE, 7EPD, 7EPB, 7EPF, 7EPA | 7MTS, 7E9G | |
| GRM3 | 3 | 7WI6, 7WI8, 7WIH | ||
| GRM4 | 1 | 7E9H | ||
| GRM5 | 11 | 4OO9, 5CGC, 5CGD, 6FFH, 6FFI, 6N4X, 6N4Y, 6N50, 6N51, 6N52, 7FD8, 7P2L, 7FD9 | ||
| GRM7 | 1 | 7EPC | ||
| GP158 | 5 | 7EWL, 7SHF, 7SHE, 7EWR, 7EWP | ||
| CASR | 16 | 7SIL, 7SIM, 7SIN, 7E6U, 7E6T, 7M3E, 7M3J, 7M3G, 7M3F, 7DD5, 7DD6, 7DD7, 7DTU,7DTW, 7DTV, 7DTT | ||
| F | FZD4 | 1 | 6BD4 | |
| FZD5 | 1 | 6WW2 | ||
| FZD7 | 1 | 7EVW |
ADRB3 beta-3 adrenergic receptor, AGTR1 type 1 angiotensin II receptor, AGTR2 type 2 angiotensin II receptor, HTR1A 5-hydroxytryptamine receptor 1A, HTR1B 5-hydroxytryptamine receptor 1B, HTR1D 5-hydroxytryptamine receptor 1D, HTR1E 5-hydroxytryptamine receptor 1E, HTR1F 5-hydroxytryptamine receptor 1F, HTR2A 5-hydroxytryptamine receptor 2A, HTR2B 5-hydroxytryptamine receptor 2B, HTR2C 5-hydroxytryptamine receptor 2C, ACM1 muscarinic acetylcholine receptor M1, ACM2 muscarinic acetylcholine receptor M2, ACM3 muscarinic acetylcholine receptor M3, ACM4 muscarinic acetylcholine receptor M4, ACM5 muscarinic acetylcholine receptor M5, APJ apelin receptor, BKRB1 B1 bradykinin receptor, BKRB2 B2 bradykinin receptor, C5AR1 C5a anaphylatoxin chemotactic receptor 1, CCKAR cholecystokinin receptor type A, CCR1 cinnamoyl-CoA reductase 1, CCR2 C-C chemokine receptor type 2, CCR5 C-C chemokine receptor type 5, CCR6 C-C chemokine receptor type 6, CCR7 C-C chemokine receptor type 7, CCR9 C-C chemokine receptor type 9, CNR1 cannabinoid receptor 1, CNR2 cannabinoid receptor 2, CXCR2 C-X-C chemokine receptor type 2, CXC-R4 C-X-C chemokine receptor type 4, DRD1 D(1A) dopamine receptor, DRD2 D(2) dopamine receptor, DRD3 D(3) dopamine receptor, DRD4 D(4) dopamine receptor, EDNRB endothelin receptor type B, FFAR1 free fatty acid receptor 1, FPR1 fMet-Leu-Phe receptor, FPR2 N-formyl peptide receptor 2, GALR1 galanin receptor type 1, GALR2 galanin receptor type 2, CCKBR gastrin/cholecystokinin type B receptor, GHSR growth hormone secretagogue receptor type 1, GNRHR gonadotropin-releasing hormone receptor, GPBAR1 G-protein coupled bile acid receptor 1, HRH1 histamine H1 receptor, LPAR1 lysophosphatidic acid receptor 1, LSHR lutropin-choriogonadotropic hormone receptor, LT4R1 leukotriene B4 receptor 1, MC4R melanocortin receptor 4, MSHR melanocyte-stimulating hormone receptor, MTNR1A melatonin receptor type 1A, MTNR1B melatonin receptor type 1B, NK1R substance-P receptor, NPY1R neuropeptide Y receptor type 1, NPY2R neuropeptide Y receptor type 2, NTSR1 neurotensin receptor type 1, OPRD delta-type opioid receptor, OPRK kappa-type opioid receptor, OPRM mu-type opioid receptor, OPRL1 nociceptin receptor, HCRTR1 orexin/hypocretin receptor type 1, HCRTR2 orexin receptor type 2, OXYR oxytocin receptor, P2RY1 P2Y purinoceptor 1, P2Y12 P2Y purinoceptor 12, PAR1 proteinase-activated receptor 1, PAR2 proteinase-activated receptor 2, PTGDR2 prostaglandin D2 receptor 2, PTGER2 prostaglandin E2 receptor EP2 subtype, PTGER3 prostaglandin E2 receptor EP3 subtype, PTGER4 prostaglandin E2 receptor EP4 subtype, PTAFR platelet-activating factor receptor, lpar6a lysophosphatidic acid receptor 6a, BLT1 leukotriene B4 receptor 1, S1PR1 sphingosine 1-phosphate receptor 1, S1PR2 sphingosine 1-phosphate receptor 2, S1PR3 sphingosine 1-phosphate receptor 3, S1PR5 sphingosine 1-phosphate receptor 5, SSR2 somatostatin receptor type 2, SUCR1 succinate receptor 1, TBXA2R thromboxane A2 receptor, V2R vasopressin V2 receptor, GPR52 G-protein coupled receptor 52, GPR88 probable G-protein coupled receptor 88, GPR139 probable G-protein coupled receptor 139, GPR183 G-protein coupled receptor 183, MRGX2 Mas-related G-protein coupled receptor member X2, MRGX4 Mas-related G-protein coupled receptor member X4, CALCR calcitonin receptor, CALRL calcitonin gene-related peptide type 1 receptor, CRFR1 corticotropin-releasing factor receptor 1, CRFR2 corticotropin-releasing factor receptor 2, GHRHR growth hormone-releasing hormone receptor, GIPR gastric inhibitory polypeptide receptor, GLP1R glucagon-like peptide-1 receptor, GLP2R glucagon-like peptide 2 receptor, GCGR glucagon receptor, SCTR secretin receptor, ADGRG1 adhesion G-protein coupled receptor G1, ADGRL3 adhesion G protein-coupled receptor L3, GABR1 gamma-aminobutyric acid type B receptor subunit 1, GABBR2 gamma-aminobutyric acid type B receptor subunit 2, GRM1 metabotropic glutamate receptor 1, GRM2 metabotropic glutamate receptor 2, GRM3 metabotropic glutamate receptor 3, GRM4 metabotropic glutamate receptor 4, GRM5 metabotropic glutamate receptor 5, GRM7 metabotropic glutamate receptor 7, GP158 probable G-protein coupled receptor 158, CASR extracellular calcium-sensing receptor, FZD4 Frizzled-4, FZD5 Frizzled-5, FZD7 Frizzled-7