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. 2023 Feb 2;114(5):1943–1957. doi: 10.1111/cas.15727

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© 2023 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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The effect of POLQ knockdown on normal pulmonary epithelial cells. (A) Analysis of the siRNA efficacy for POLQ knockdown using qRT‐PCR. (B) EdU essay showing that POLQ silencing does not inhibit the proliferation of BEAS‐2B cells. (C) Representative images and quantification of γH2AX foci in BEAS‐2B cells pretreated with POLQ siRNA or NVB. (D) Cell cycle distribution is examined in POLQ‐silenced or NVB‐treated BEAS‐2B cells 24 h after irradiation (6 Gy). (E) The apoptotic rate was examined in POLQ‐silenced or NVB‐treated BEAS‐2B cells 48 h after irradiation (6 Gy).