TABLE 3.
Multivariate analysis of 5‐year overall survival of hepatocellular carcinoma cases by Cox proportional hazards model
| Parameters | Number | HR | 95% CI | p value |
|---|---|---|---|---|
| General background | ||||
| Age (≥60 years/<60 years) | 351/61 | 2.35 | 1.33–4.17 | 0.003 |
| Tumor factor | ||||
| Tumor number (>2/1) | 134/278 | 1.97 | 1.42–2.73 | <0.0001 |
| Tumor size (≥5 cm/<5 cm) | 176/236 | 1.68 | 1.18–2.38 | 0.004 |
| Vascular invasion (positive/negative) | 155/257 | 1.69 | 1.18–2.40 | 0.004 |
| DKK1/CKAP4 expression | ||||
| DKK1+/CKAP4+ vs. DKK1 − CKAP4− | 55/159 | 2.89 | 1.87–4.48 | <0.0001 |
| DKK1+/CKAP4+ vs. DKK1 + CKAP4− | 55/162 | 3.31 | 2.11–5.17 | <0.0001 |
| DKK1+/CKAP4+ vs. DKK1 − CKAP4+ | 55/36 | 4.19 | 2.06–8.54 | <0.0001 |
Abbreviations: CI, confidence interval; CKAP4, cytoskeleton‐associated protein 4; DKK1, Dickkopf‐1; HB, hepatitis B; HC, hepatitis C; HCC, hepatocellular carcinoma; non‐B non‐C, non‐hepatitis B and non‐hepatitis C; HR, hazard ratio.