TABLE 5.
Multivariate analysis of 5‐year relapse‐free survival of hepatocellular carcinoma cases by Cox proportional hazards model
| Parameters | Number | HR | 95% CI | p value |
|---|---|---|---|---|
| General background | ||||
| Age (≥60 years/<60 years) | 351/61 | 1.34 | 0.90–1.99 | 0.145 |
| Sex (male/female) | 351/61 | 0.64 | 0.45–0.90 | 0.011 |
| Tumor factor | ||||
| Tumor number (>2/1) | 134/278 | 2.26 | 1.73–2.95 | <0.0001 |
| Tumor size (≥5 cm/<5 cm) | 176/236 | 1.40 | 1.06–1.84 | 0.018 |
| Vascular invasion (positive/negative) | 155/257 | 1.51 | 1.14–2.00 | 0.004 |
| Capsular invasion (positive/negative) | 284/123 | 1.21 | 0.90–1.64 | 0.204 |
| DKK1/CKAP4 expression | ||||
| DKK1+/CKAP4+ vs. DKK1 − CKAP4− | 55/159 | 2.61 | 1.78–3.79 | <0.0001 |
| DKK1+/CKAP4+ vs. DKK1 + CKAP4− | 55/162 | 2.61 | 1.78–3.81 | <0.0001 |
| DKK1+/CKAP4+ vs. DKK1 − CKAP4+ | 55/36 | 4.17 | 2.32–7.49 | <0.0001 |
Note: p values ≤0.05 are statistically significant.
Abbreviations: CI, confidence interval; CKAP4, cytoskeleton‐associated protein 4; DKK1, Dickkopf‐1; HB, hepatitis B; HC, hepatitis C; non‐B non‐C, non‐hepatitis B and non‐hepatitis C; HR, hazard ratio.