FIGURE 7.

Epidermal growth factor‐like protein 6 (EGFL6) mediates the proangiogenesis of formin‐like 2 (FMNL2) in vivo. (A, B) Mice of the xenograft model were subcutaneously injected with HCT116 cells transfected with EGFL6 overexpressing plasmids, control plasmids, or shFMNL2/EGFL6 plasmids. Tumor weights were monitored after 5 weeks. n = 6 for each group. (C, D) Mice of the metastatic liver model of orthotopic cecal implantation were injected with HCT116 cells transfected with EGFL6 overexpressing plasmids, control plasmids, or shFMNL2/EGFL6 plasmids. n = 5 for each group. (E) Representative images of CD31, EGFL6, and FMNL2 immunohistochemical staining of paraffin‐embedded tumor samples from different mice xenograft model groups. **p < 0.01, ***p < 0.001