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. 2023 Feb 14;114(5):2001–2013. doi: 10.1111/cas.15741

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© 2023 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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GNB1 promotes tumorigenicity in nude mice. (A) HLF cells stably transfected with control or GNB1 were injected into the flank of nude mice. After the tumors grew to 3–5 mm in diameter, mice with GNB1 overexpression HLF cells were treated with SB202190 (5 mg/kg, daily for 10–12 days). Photos for xenograft tumors isolated from nude mice 21 days post‐inoculation. (B) Tumor volume and weight were compared between the three groups at the end of the experiment. **p < 0.01, one‐way ANOVA. (C) The expression of GNB1, Ki67, occludin and BAG2 in indicated subcutaneous xenografts was determined by immunohistochemistry (IHC). Scale bar, 50 μm. (D) The levels of GNB1, N‐cadherin, occludin, and BAG2 were analyzed by western blotting from three representative xenograft tumors in each group.