Table 5.

Select Studies of Individuals With an Incidentally Detected Lung Nodule Demonstrating Both Common and Heterogenous Findings

Variable	Farjah et al2	Gould et al1	Vachani et al32	Wiener et al33	Gould et al11	Swensen et al10	Tanner et al31	Verdial et al30	Herder et al13	Deppen et al14
Context and setting	Population-based	Population-based	Population-based, nodule > 8 mm	Veteran’s Affairs	Veteran’s Affairs	Referral to quaternary institution	Referral to pulmonary clinic	Referral to multidisciplinary nodule clinic	Referred for PET imaging	Referred to thoracic surgery
No.	7,240	68,998	23,780	300	375	629	377	113	106	492
Age,a y	66	63	65	66	66	61	65	NR	64 ± NR	63 ± 13
Women, %	56	56	53	6	2	51	55	58	36	49
Ever smokers, %	56	56	46	86	94	68	73	69	65	77
BMI,a kg/m2	29	NR	28	NR	NR	NR	NR	NR	NR	28 ± 6
Prior malignancy, %	31	NR	NAb	NAb	17	NAb	NAb	9c	8	37
Nodule size,a mm	7	NR	16	NR	17	13	13	NR	NR	28 ± 19
Nodule spiculation, %	NR	NR	NR	11	NR	15	31	26	35	45
Nodule density, %
Solid	NR	NR	NAd	NR	NR	NR	NR	88	NR	NR
Part solid	NR	NR	NAd	NR	NR	NR	NR	11	NR	NR
Ground-glass opacity	NR	NR	NAd	13	NR	NR	NR	3	NR	NR
Multiple nodules, %	57	NR	NR	NR	NA	NA	NR	61	NR	NAa
Upper lobe location, %	40	NR	38	36	50	44	47	51	58	59
Lung cancer diagnosis, %	3.7	5.2	9.9	9.0	54	23	25	29	58	78

NA = not available; NR = not reported.

^aAll continuous variables summarized by mean values (most commonly reported summary statistic).

^bNot available, because prior malignancy was an exclusion criterion.

^cFrequency of prior malignancy > 5 y prior to nodule detection.

^dNot available, because the frequency of missing data was > 20%.