Table 7.
Within-participant change in hyperphagia questionnaire subscales during each treatment block), accounting for baseline subscale values at the beginning of each treatment block
| Factor | Model 1 Hyperphagia – Behavior (N = 13) |
Model 2 Hyperphagia – Severity (N = 13) |
Model 3 Hyperphagia – Drive (N = 13) |
Model 4 Hyperphagia – Total Score (N = 13) |
|---|---|---|---|---|
| β coefficient (95% CI) |
β coefficient (95% CI) |
β coefficient (95% CI) |
β coefficient (95% CI) |
|
| Treatment (OXT, reference = PBO) | −2.39 (−6.19, 1.41) |
0.03 (−0.43, 0.50) |
−0.94 (−2.77, 0.90) |
0.33 (−1.17, 1.82) |
| Block in study (Block 2, reference = Block 1) | 3.43 (−0.39, 7.25) |
−0.02 (−0.49, 0.45) |
0.17 (−1.75, 2.01) |
−1.89 (−3.39, −0.40) |
| Outcome of interest at the beginning of each treatment block | 0.06 (−0.32, 0.45) |
0.03 (−0.23, 0.29) |
0.34*
(0.05, 0.62) |
0.34*
(0.09, 0.69) |
| Treatment duration (number of days within the Block when outcome was measured) | −0.04 (−0.19, 0.11) |
0.02 (−0.03, 0.06) |
−0.01 (−0.12, 0.11) |
0.03 (−0.11, 0.17) |
Mixed-effects models of other outcomes of interest were also constructed. The “treatment duration” variable reflects the time (in days) in within the treatment Block when the outcome was measured. Statistical significance is indicated by bold text; *P < 0.05.