Table 1 ∣.
Dynobactin A minimum inhibitory concentrations
| MIC | |
|---|---|
| Gram-negative bacteria | μg ml−1 |
| Escherichia coli ATCC 25922 | 8 |
| +10% FBS | 8 |
| Escherichia coli K-12 MG1655 | 16 |
| Strain 1, BamA (G429V, G807V) | >128 |
| Strain 2, BamA (F394V, E435K, G443D) | 16 |
| Strain 3, BamA (T434A, Q445P, A705T) | 16 |
| Escherichia coli AR350 | 8 |
| Shigella sonnei ATCC 25931 | 4 |
| Shigella flexneri KLE 2512 | 8 |
| Salmonella enterica typhimurium LT2 ATCC 19585 | 8 |
| Salmonella enterica Enteritidis AR496 | 8 |
| Enterobacter cloaceae ATCC 13047 | 16 |
| Klebsiella pneumoniae AR347 | 64 |
| Pseudomonas aeruginosa PA01 | 8 |
| Pseudomonas aeruginosa PA14 | 16 |
| Acinetobacter baumannii ATCC 19606 | 16 |
| Moraxella catarrhalis ATCC 25238 | 2 |
| Yersinia pseudotuberculosis ATCC 6904 | 8 |
| Vibrio vulnificus KLE δ-1125 | 8 |
| Veillonella ratti KLE 2365 | 16 |
| Bacteroides fragilis KLE 2244 | >128 |
| Bacteroides stercoris KLE 2537 | >128 |
| Photorhabdus australis DSM 17609 | >128 |
| Gram-positive bacteria | |
| Staphylococcus aureus HG003 | >1000 |
| Bacillus subtilis 168 | >1000 |
| Limosilactobacillus reuteri LTH5448 | >128 |
| Clostridium bifermentans KLE 2329 | >128 |
| Human cell lines | |
| FaDu (Epithelium) | >1000 |
| HepG2 (Hepatocytes) | >1000 |
| HEK293 (Embryonic kidney) | >1000 |
| A549 (Lung epithelium) | >1000 |
MICs and cytotoxicity data for pathogens, human gut microbiome members and human cell lines. MICs were determined in biological triplicate.