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. 2023 May 3;16:46. doi: 10.1186/s13045-023-01442-4

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Identification of myeloid-like disseminated cancer cells in the bone marrow of patients with PCa bone metastasis. a UMAP plots showing the populations of 55,276 cells from the three combined scRNA-seq (tumor in bone, involved marrow, and distal marrow) of patients with PCa, colored by cell annotation. b UMAP plots showing the transcription heterogeneity of tumor cells colored by cell cluster (left) and sample type (right). d Dot plots showing the average expression level of known markers in tumor cells from different types of samples. c UMAP plots showing the expression level of selected genes in tumor cells. e Volcano plots showing the differentially expressed genes between myeloid-like tumor cells and normal tumor cells. f Dot plot showing GO enrichment analysis of up-regulated genes in myeloid-like tumor cells. g Bar plot showing the result of GSEA of hallmark pathways in cluster 6 (myeloid-like tumor cells) compared with cluster 3