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. 2023 May 3;16:46. doi: 10.1186/s13045-023-01442-4

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Single-cell RNA sequencing reveals the tumor microenvironment in RM1 and hybrid cell-derived tumors. a UMAP plots showing the 17 identified clusters of 17,602 cells from scRNA-seq of RM1-derived tumor and hybrid cell-derived tumor. The cells from RM1-derived tumor (middle) and hybrid cell-derived tumor (right) are shown. b UMAP plots showing the clusters colored by cell type. c Dot plots showing the expression level of known markers for each cell type. d UAMP plot showing the expression level of selected genes in all cells. e Pie plots showing the components of non-tumor cells colored by cell annotation. f–h Violin plot showing the expression of N1 TAN markers and N2 TAN markers in neutrophils (f), M-MDSC markers in monocytes (g), TAM markers in macrophages (h) from RM1-derived and hybrid cell-derived tumors. i, j Bar plots showing the results of GSEA of GOBP pathways in monocytes (i) and macrophages (j) from hybrid cell-derived tumors compared with those from RM1-derived tumors. ***P < 0.001