Fig. 1.

β-amyloid (Aβ) burden and sleep-related cognitive reserve in the Aβ+ and Aβ- groups. A Mean voxelwise ¹¹C-PiB DVR PET maps in the Aβ+ (left) and Aβ- (right) groups demonstrating Aβ distribution. B Association between item memory and NREM SWA averaged across the scalp (indexed by relative delta bandpower) in the Aβ+ (red) and Aβ- (blue) groups after adjusting for age, sex, BMI, gray matter atrophy, education, physical activity, and the time difference between the PET and sleep sessions. NREM SWA supported superior memory function in individuals suffering high Aβ burden, i.e., those most in need of cognitive reserve, and not in those without such pathological abutment needs, i.e., those with low Aβ burden (regression line, 95% confidence interval, and individual subject data points illustrated in red and blue for each respective group). C EEG topographic plot of NREM SWA predicting memory function in the Aβ+ group (slopes adjusted for age, sex, BMI, gray matter atrophy, education, physical activity, and the time difference between the PET and sleep sessions). Asterisks indicate FDR corrected ps < 0.05. The strength of the associations was comparable over the scalp with the strongest associations observed over right frontal regions