Figure 2.
Pathological histology analysis shows aggravated lung, liver, and pancreas damage in db/db mice infected with SARS-CoV-2. WT and db/db mice were infected intranasally with 1 × 105 PFU of the alpha strain or PBS. Lungs, livers, and pancreases were collected on 7 dpi. (A) H&E staining of lungs, livers and pancreas sections from WT-PBS, WT-alpha, db/db-PBS and db/db-alpha. Pathological score of lungs(B), livers(C) and pancreases(D). Data are presented as mean ± SEM. The difference between two groups were determined by Manna-Whitney test in non-parametric tests. *p < 0.05; **p < 0.01; ***p < 0.001. Each group contains 5–6 mice. Scale bar 100 μm.