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. 2023 May 1;12(1):2203782. doi: 10.1080/22221751.2023.2203782

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© 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group, on behalf of Shanghai Shangyixun Cultural Communication Co., Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

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Figure 3. — Inflammation related factor level and diabetic related cytokine level in serum was altered in db/db mice following SARS-Cov-2 infection. WT and db/db mice were infected intranasally with 1 × 10⁵ PFU of the alpha strain or PBS. Serum was collected on 7 dpi. Inflammation factors including (A) Eotaxin, (B) MCP-1, (C) G-CS, (D)KC, (E) IL-12(p40), (F) IL-5, and so on was determined using Bio-Plex Peo^TM assays. Protein expression of diabetic related cytokine such as (G) insulin, (H) PAI-1, (I) leptin and so on was determined using Bio-Plex Mouse Diabetes assays. (J) HOMA-IR value of mice on 7 dpi. The difference between two groups was determined by unpaired t-test. *p < 0.05; **p < 0.01; ***p < 0.001. Each group contained 5–6 mice. All data was presented as mean ± SEM.