Table 5.
Univariate and Multivariate Logistic Regression Analysis of Predictors for Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage
| Variable | Univariate Analysis | Multivariate Analysis | ||
|---|---|---|---|---|
| OR (95% CI) | P value | OR (95% CI) | P value | |
| Gender (male/female) | 0.632 (0.286–1.400) | 0.258 | – | |
| Age (years) | 1.012 (0.976–1.049) | 0.524 | – | |
| Cigarette smoking | 1.303 (0.503–3.378) | 0.586 | – | |
| Alcohol consumption | 0.664 (0.256–1.718) | 0.398 | – | |
| Hypertension | 0.712 (0.273–1.859) | 0.488 | – | |
| Diabetes mellitus | 0.945 (0.279–3.400) | 0.928 | – | |
| Hyperlipidemia | 2.310 (0.871–6.124) | 0.092 | – | |
| WFNS score | 2.407 (1.626–3.563) | <0.001* | 1.850 (1.061–3.226) | 0.030* |
| Modified Fisher score | 2.081 (1.388–3.120) | <0.001* | 0.825 (0.441–1.543) | 0.547 |
| Aneurysmal position (posterior / anterior circulation) | 0.526 (0.211–1.313) | 0.169 | – | |
| Aneurysmal shape (cystic/others) | 1.271 (0.426–3.790) | 0.667 | – | |
| Aneurysmal diameter (<10 mm/≥10 mm) | 0.970 (0.434–2.167) | 0.941 | – | |
| Surgery (clipping/ endovascular intervention) | 0.695 (0.313–1.544) | 0.372 | – | |
| Intraventricular bleeding | 3.788 (1.426–10.009) | 0.007* | 1.100 (0.302–4.008) | 0.885 |
| Acute hydrocephalus | 3.704 (1.350–10.164) | 0.011* | 3.067 (0.815–11.541) | 0.097 |
| External ventricular drain | 1.838 (0.647–5.221) | 0.253 | – | |
| Admission time (h) | 1.000 (0.931–1.073) | 0.991 | – | |
| Blood-collection time (h) | 1.000 (0.933–1.071) | 0.996 | – | |
| Systolic arterial pressure (mmHg) | 0.989 (0.969–1.010) | 0.314 | – | |
| Diastolic arterial pressure (mmHg) | 1.015 (0.986–1.044) | 0.311 | – | |
| Blood leucocyte count (×109/L) | 1.186 (1.024–1.374) | 0.023* | 1.062 (0.903–1.250) | 0.467 |
| Blood potassium concentrations (mmol/L) | 0.780 (0.311–1.956) | 0.596 | – | |
| Blood glucose concentrations (mmol/L) | 1.113 (1.015–1.222) | 0.023* | 1.052 (0.938–1.179) | 0.386 |
| Serum NOX2 levels > 2364.86 pg/mL | 6.771 (2.839–16.149) | <0.001* | 2.978 (1.008–8.803) | 0.048* |
Notes: Results were presented as odds ratio (95% confidence interval) using the univariate and multivariate logistic regression analysis. The asterisk indicates statistical significance (*P<0.05).
Abbreviations: CI, confidence interval; WFNS, World Federation of Neurological Societies Scale; NOX2, NADPH oxidase 2.