Table 6.
Factors Associated with 90-Day Poor Prognosis in Aneurysmal Subarachnoid Hemorrhage
| Variable | 90-Day Poor Prognosis | Z | χ2 | P value | |
|---|---|---|---|---|---|
| Presence (n=47) | Absence (n=76) | ||||
| Gender (male/female) | 21/26 | 34/42 | – | 1.286 | 0.257 |
| Age (years) | 55.2±12.0 | 54.0±10.6 | −0.859 | – | 0.390 |
| Cigarette smoking | 10 (21.3%) | 15 (19.7%) | – | 0.043 | 0.837 |
| Alcohol consumption | 8 (17.0%) | 24 (31.6%) | – | 3.197 | 0.074 |
| Hypertension | 9 (19.1%) | 15 (19.7%) | – | 0.006 | 0.936 |
| Diabetes mellitus | 7 (14.9%) | 8 (10.5%) | – | 0.517 | 0.472 |
| Hyperlipidemia | 9 (19.1%) | 12 (15.8%) | – | 0.231 | 0.630 |
| WFNS score | 4 (3–5) | 2 (2–3) | −5.420 | – | <0.001* |
| Modified Fisher score | 3 (2–4) | 2 (1–2) | −5.836 | – | <0.001* |
| Aneurysmal position (posterior / anterior circulation) | 34/13 | 63/13 | – | 1.929 | 0.164 |
| Aneurysmal shape (cystic/others) | 38/9 | 64/12 | – | 0.186 | 0.630 |
| Aneurysmal diameter (<10 mm/≥10 mm) | 29/18 | 44/32 | – | 0.005 | 0.676 |
| Surgery (clipping/ endovascular intervention) | 19/28 | 31/45 | – | 0.800 | 0.968 |
| Intraventricular bleeding | 14 (29.8%) | 7 (9.2%) | – | 8.685 | 0.003* |
| Acute hydrocephalus | 12 (25.5%) | 7 (9.2%) | – | 5.923 | 0.015* |
| External ventricular drain | 8 (17.0%) | 10 (13.2%) | – | 0.347 | 0.556 |
| Admission time (h) | 7.0 (4.0–11.0) | 7.0 (5.0–11.0) | −0.697 | – | 0.486 |
| Blood-collection time (h) | 7.2 (4.5–12.0) | 8.1 (5.2–12.0) | −0.791 | – | 0.429 |
| Systolic arterial pressure (mmHg) | 147 (129–157) | 149 (137–163) | −1.062 | – | 0.288 |
| Diastolic arterial pressure (mmHg) | 86.6±14.4 | 87.1±14.4 | −0.010 | – | 0.992 |
| Blood leucocyte count (×109/L) | 10.1±3.0 | 8.3±2.4 | −3.394 | – | 0.001* |
| Blood potassium concentrations (mmol/L) | 3.81±0.53 | 3.78±0.37 | −0.034 | – | 0.973 |
| Blood glucose concentrations (mmol/L) | 8.20 (6.40–13.60) | 7.10 (5.30–8.80) | −2.788 | – | 0.005* |
| Serum NOX2 levels > 2364.86 pg/mL | 35 (74.5%) | 16 (21.1%) | – | 34.139 | <0.001* |
Notes: Qualitative variables were presented as counts (percentages) and were compared for intergroup difference using chi-square test or Fisher exact test as appropriate. Quantitative variables were summarized as medians (upper - lower quartiles) or the means ± standard deviations as appropriate. Intergroup comparisons were done using unpaired Student t-test or Mann–Whitney U-test where appropriate. Modified Rankin scale of 3–6 was designated as poor prognosis. The asterisk indicates statistical significance (*P<0.05).
Abbreviations: WFNS, World Federation of Neurological Societies Scale; NOX2, NADPH oxidase 2.