Table 7.
Univariate and Multivariate Logistic Regression Analysis of Predictors for 90-Day Poor Prognosis After Aneurysmal Subarachnoid Hemorrhage
| Variable | Univariate Analysis | Multivariate Analysis | ||
|---|---|---|---|---|
| OR (95% CI) | P value | OR (95% CI) | P value | |
| Gender (male/female) | 1.002 (0.482–2.083) | 0.995 | – | |
| Age (years) | 1.010 (0.977–1.044) | 0.548 | – | |
| Cigarette smoking | 1.099 (0.448–2.699) | 0.837 | – | |
| Alcohol consumption | 0.444 (0.180–1.095) | 0.078 | – | |
| Hypertension | 1.038 (0.414–2.606) | 0.936 | – | |
| Diabetes mellitus | 1.487 (0.502–4.411) | 0.474 | – | |
| Hyperlipidemia | 1.263 (0.487–3.276) | 0.631 | – | |
| WFNS score | 2.551 (1.768–3.681) | <0.001* | 1.038 (0.603–1.787) | 0.893 |
| Modified Fisher score | 3.557 (2.246–5.633) | <0.001* | 2.088 (1.092–3.992) | 0.026* |
| Aneurysmal position (posterior / anterior circulation) | 0.540 (0.225–1.294) | 0.167 | – | |
| Aneurysmal shape (cystic/others) | 0.792 (0.305–2.053) | 0.631 | – | |
| Aneurysmal diameter (<10 mm/≥10 mm) | 1.172 (0.557–2.465) | 0.676 | – | |
| Surgery (clipping/ endovascular intervention) | 1.015 (0.484–2.129) | 0.968 | – | |
| Intraventricular bleeding | 4.182 (1.542–11.340) | 0.005* | 0.879 (0.196–3.931) | 0.866 |
| Acute hydrocephalus | 3.380 (1.222–9.344) | 0.019* | 3.491 (0.824–14.796) | 0.090 |
| External ventricular drain | 1.354 (0.493–3.719) | 0.557 | – | |
| Admission time (h) | 0.975 (0.912–1.042) | 0.455 | – | |
| Blood-collection time (h) | 0.972 (0.911–1.038) | 0.396 | – | |
| Systolic arterial pressure (mmHg) | 0.988 (0.970–1.008) | 0.233 | – | |
| Diastolic arterial pressure (mmHg) | 0.998 (0.972–1.023) | 0.849 | – | |
| Blood leucocyte count (×109/L) | 1.286 (1.109–1.491) | 0.001* | 1.166 (0.981–1.386) | 0.082 |
| Blood potassium concentrations (mmol/L) | 1.174 (0.511–2.698) | 0.705 | – | |
| Blood glucose concentrations (mmol/L) | 1.140 (1.038–1.251) | 0.006* | 1.102 (0.972–1.250) | 0.131 |
| Serum NOX2 levels > 2364.86 pg/mL | 10.937 (4.643–25.763) | <0.001* | 5.133 (1.723–15.291) | 0.003* |
Notes: Results were presented as odds ratio (95% confidence interval) using the univariate and multivariate logistic regression analysis. Modified Rankin scale of 3–6 was designated as poor prognosis. The asterisk indicates statistical significance (*P<0.05).
Abbreviations: CI, confidence interval; WFNS, World Federation of Neurological Societies Scale; NOX2, NADPH oxidase 2.