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. 2023 Apr 19;14:1138666. doi: 10.3389/fphar.2023.1138666

FIGURE 5.

FIGURE 5

Intraperitoneal injection of benzodiazepine induces sleep in mice with mania-like behavior. (A–O) Time course (A–F), total amount (G–I), mean duration (J–L), and episode number (M–O) of SWS, REMS, and wakefulness in VGAT-CreDTA/VMP and VGAT-CrehrGFP/VMP mice after administering vehicle or diazepam. (P) Wake episode spectrum in VGAT-CreDTA/VMP mice. (Q) Latency to sleep onset in VGAT-CreDTA/VMP and VGAT-CrehrGFP/VMP mice after administering vehicle or diazepam. (R,S) SWS EEG power density for 6 h after injection of vehicle or diazepam into VGAT-CreDTA/VMP (R) and VGAT-CrehrGFP/VMP (S) mice. Bars indicate statistical significance (p < 0.05). Data (n = 6/group) are presented as mean ± SEM. Significance levels are indicated as *p < 0.05, **p < 0.01, and ***p < 0.001.